WHAT IS THE "METABOLIC SYNDROME"?

Metabolic Syndrome (MetS) is a set of risk factors which significantly increase the chance of developing diabetes, heart disease, and stroke. Proper dietary changes, weight loss and exercise may help improve and defer Metabolic Syndrome, and perhaps even reverse its process. Other names given to this condition include insulin resistance syndrome, dysmetabolic syndrome, and Syndrome X. According to a US national health survey (NHANES 1988-2012), more than 1 in 5 Americans have Metabolic Syndrome. Its incidence increases with age, and among those in their 60s and 70s, it affects more than 40%. For the Asia-Pacific region, in a systematic review it has been noted that "in most countries nearly 1/5th of the adult population or more were affected by Metabolic Syndrome with a secular increase in prevalence." A systematic review done among the young in 2020 showed that globally, about 3% of children and 5% of adolescents had Metabolic Syndrome, with some variation across countries and regions.

Based on WHO estimates, Metabolic Syndrome and all its associated complications cause the greatest number of non-communicable disease deaths worldwide. To make the long story short, METABOLIC SYNDROME is the No. 1 killer in the world today! We all have to wake up to the truth: it is an URGENT PROBLEM the whole world is currently facing!

WHO TYPICALLY HAS "METABOLIC SYNDROME"?

• People with type 2 diabetes mellitus (T2DM) or a strong family history of T2DM

• People with central obesity/visceral adiposity (increased fat in the abdomen/waist)

• People who have cardiovascular disease (such as coronary artery disease or CAD and myocardial infarction or “heart attack”)

• People who have cerebrovascular disease or stroke or “brain attack” (both ischemic stroke and hemorrhagic stroke)

• People with other clinical features of "insulin resistance" including skin changes of acanthosis nigricans ("darkened skin" on the back of the neck or underarms) or skin tags (usually on the neck), polycystic ovarian syndrome (PCOS), and fatty liver changes

• Certain ethnic backgrounds are at a higher risk of developing Metabolic Syndrome

WHAT CAUSES "METABOLIC SYNDROME"?

As of the present, the exact cause of Metabolic Syndrome is not yet totally known. However, a lot of its features are associated with "insulin resistance" or “carbohydrate intolerance.” Insulin resistance is a state wherein certain cells of the body (e.g. the muscle cell) do not efficiently use insulin for glucose uptake – because of recurrent exposure to high levels of glucose and corresponding high levels of insulin. Chronically high levels of insulin in the blood – otherwise known as "hyperinsulinemia" – is not physiologically normal. Thus, high blood glucose levels persist, and some of them are converted to triglycerides in the liver via de novo lipogenesis (DNL), which leads to non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), with excess triglycerides going to the bloodstream elevating the triglyceride levels in the blood (hypertriglyceridemia). Chronic high levels of glucose (hyperglycemia) and insulin (hyperinsulinemia) also leads to many other metabolic syndrome-related complications such as what has been called as "essential" hypertension, type 2 diabetes, abnormal growth of cells leading to tumors and many neoplasms, dementia and other neurodegenerative diseases due the development of brain insulin resistance, as well as polycystic ovarian syndrome (PCOS) among women. More and more evidence are growing pointing to mitochondrial dysfunction as a common denominator linking together these "modern day lifestyle-related" disease entities.

Insulin resistance may be due to a combination of genetic and lifestyle factors. Included among these lifestyle factors are 😵 dietary habits (especially diets high in addictive refined carbohydrates such as sugars and flour-containing products and habitual frequent eating especially with carbohydrate-rich foods even when not hungry) that lead to chronic excessive glucose levels beyond what the body demands for its energy needs, 😵 a chronically stressful lifestyle, 😵 lack of regular physical activity and/or exercise and perhaps even 😵 lack of sufficient and restful sleep or interrupted sleep patterns (such as that seen in sleep apnea) — all of which may lead to chronic and persistent low level systemic inflammation.